Dai Yabin, Liu Mei, Li Wenliang
Poultry Institute, Chinese Academy of Agricultural Sciences, 46 Sangyuan Road, Yangzhou, Jiangsu 225003, China.
Avian Dis. 2008 Sep;52(3):467-71. doi: 10.1637/8239-013008-Reg.1.
Since 1997, severe outbreaks of Newcastle disease (ND) in geese in many regions throughout China have resulted in high morbidity and mortality, and great economic loss to farmers; however, no licensed, specific vaccine is yet available for this disease in China. In this study, goslings were immunized with different combinations and dosages of several commercial ND vaccines including La Sota vaccine, Mukteswar vaccine, recombinant live vaccine against avian influenza (AI) and ND (rL-H5 strain), and inactivated ND oil-emulsion vaccine (La Sota strain). The protective effects were evaluated based upon the level of antibody response and the degree of protection against the goose-origin virulent NDV strain. The result showed that two doses (i.e., one more than that for chicken) of La Sota vaccine priming, followed by 2-5 doses of Mukteswar vaccine boosting 2-3 weeks later, not only induced higher HI antibody levels, but also conferred longer-lasting protection. This immunization procedure can be recommended for prevention of ND in geese.
自1997年以来，中国许多地区的鹅群中爆发了严重的新城疫（ND），导致高发病率和高死亡率，给养殖户造成了巨大的经济损失；然而，中国目前尚无针对该病的许可专用疫苗。在本研究中，用几种商业新城疫疫苗的不同组合和剂量对雏鹅进行免疫接种，这些疫苗包括La Sota疫苗、Mukteswar疫苗、重组禽流感（AI）和新城疫活疫苗（rL-H5株）以及新城疫灭活油乳剂疫苗（La Sota株）。根据抗体反应水平和对鹅源强毒新城疫病毒株的保护程度评估保护效果。结果表明，两剂（即比鸡的剂量多一剂）La Sota疫苗初免，2-3周后再用2-5剂Mukteswar疫苗加强免疫，不仅能诱导更高的血凝抑制（HI）抗体水平，还能提供更持久的保护。这种免疫程序可推荐用于预防鹅的新城疫。
