Fesler F A
Psychiatry Service, Department of Veterans Affairs Medical Center, Seattle, WA 98108.
J Clin Psychiatry. 1991 Sep;52(9):361-4.
The symptoms of posttraumatic stress disorder (PTSD) suggest sympathetic nervous system hyperarousal and hyperreactivity. Pathophysiology of this condition may include stress-activated limbic kindling. Antikindling agents lithium and carbamazepine have been found effective for PTSD symptoms of intrusive reexperiencing and increased arousal. These facts suggest that valproate, another drug shown to interfere with limbic kindling, could also be effective for treatment of PTSD.
An open clinical trial of valproate was conducted in 16 Vietnam veterans diagnosed with DSM-III-R combat-related PTSD.
Ten of 16 patients showed significant improvement, especially in hyperarousal/hyperreactivity symptoms.
The efficacy of valproate in the treatment of PTSD should be rigorously studied.
创伤后应激障碍（PTSD）的症状提示交感神经系统过度觉醒和反应过度。该病症的病理生理学可能包括应激激活的边缘系统点燃。已发现抗点燃剂锂和卡马西平对PTSD的侵入性再体验和觉醒增加症状有效。这些事实表明，另一种显示可干扰边缘系统点燃的药物丙戊酸盐也可能对PTSD治疗有效。
对16名被诊断为与DSM-III-R战斗相关PTSD的越南退伍军人进行了丙戊酸盐的开放临床试验。
16名患者中有10名显示出显著改善，尤其是在过度觉醒/反应过度症状方面。
应严格研究丙戊酸盐治疗PTSD的疗效。
