[粒细胞集落刺激因子（G-CSF）对修复性骨生成的影响]
[Influence of granulocytic colony-stimulating factor (G-CSF) on reparative osteogenesis].
作者信息
Bazarnyĭ V V, Krokhina N B, Isaĭkin A I, Tikhonina E A
出版信息
Patol Fiziol Eksp Ter. 2008 Jul-Sep(3):26-7.
PMID:18946909
Abstract
The effect of recombinant G-CSF (50 mg/day for 3 days) on reparative osteogenesis in rats was studied on the model of induced osteogenesis after resection of a tibial fragment resection. Reparative processes in the bone tissue were estimated by histological picture and activity of serum alkaline phosphatase. The conclusion is made that G-CSF inhibits reparative osteogenesis.
摘要
在大鼠胫骨片段切除后诱导成骨模型上，研究了重组人粒细胞集落刺激因子（50毫克/天，共3天）对大鼠修复性骨生成的影响。通过组织学图像和血清碱性磷酸酶活性评估骨组织中的修复过程。得出的结论是，粒细胞集落刺激因子抑制修复性骨生成。
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