Hatano Bunpei, Nagahashi Keita, Kijima Tatsuro
Division of Chemistry, Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, 992-8510, Japan.
J Org Chem. 2008 Nov 21;73(22):9188-91. doi: 10.1021/jo8019797. Epub 2008 Oct 24.
An alkylation of aminals with organozinc reagents derived from allyl bromide, benzyl bromide, alpha-bromoacetate, and alpha-bromonitrile proceeded efficiently in the presence of TMSCl and diisopropylamine. This reaction system was applied to the synthesis of an antispasmodic: butaverine.
