Biagi G L, Guerra M C, Barbaro A M, Sapone A, Recantini M
Istituto di Farmacologia, Università di Bologna, Italy.
J Chromatogr. 1991 Jun 28;547(1-2):523-30. doi: 10.1016/s0021-9673(01)88683-0.
The RM for a new series of cardiac glycosides were calculated by means of some of the delta RM values previously derived from another series of compounds. The experimental or calculated RM values of both series of derivatives were correlated with the acute toxicity data (log 1/C). The slopes of the linear equations for cats, dogs, guinea-pigs and frogs are very close, showing that the dependence of toxicity on the lipophilic character is the same in these animal species.
通过先前从另一系列化合物中得出的一些δRM值，计算出了一系列新的强心苷的RM值。这两个系列衍生物的实验值或计算值与急性毒性数据（log 1/C）相关。猫、狗、豚鼠和青蛙的线性方程斜率非常接近，表明在这些动物物种中，毒性对亲脂性的依赖性是相同的。
