Kawatra Vibha, Gupta Parul, Khurana Nita
Department of Pathology, Maulana Azad Medical College and Lok Nayak Hospital, Bahadur Shah Zafar Marg, New Delhi 110002, India.
Cases J. 2008 Oct 23;1(1):264. doi: 10.1186/1757-1626-1-264.
Ovarian fibroma is a rare neoplasm and the one with focal proliferations of sex cord type elements is rarer. Histopathological importance lies in the recognition of this entity due to the diagnostic dilemmas that these tumors can pose. To the best of our knowledge only 9 cases of ovarian fibroma with minor sex cord elements have been documented in world literature till date.
We report the case of a 65-year-old Indian female who presented with postmenopausal bleeding and pain abdomen. An ultrasound scan of the abdomen revealed a right ovarian mass. Histologically, the ovarian tumor was a fibroma with minor sex cord elements.
Clinical manifestations of a hyperestrogenic state in postmenopausal female should raise suspicion of this entity in the mind of a physician. Also a thorough evaluation of an ovarian fibroma would help detection of minor sex cord elements within the tumor and thus be a stepping stone for better evaluation of the pathogenesis and clinical behaviour of these tumors. A close follow up of the patient should be done as hyperestrogenemia may predispose to endometrial cancer.
卵巢纤维瘤是一种罕见的肿瘤,而伴有性索样成分局灶性增生的情况则更为罕见。由于这些肿瘤可能带来诊断难题,其组织病理学意义在于对该实体的识别。据我们所知,迄今为止世界文献中仅记录了9例伴有少量性索成分的卵巢纤维瘤病例。
我们报告了一例65岁的印度女性病例,该患者出现绝经后出血和腹痛症状。腹部超声扫描显示右侧卵巢有肿块。组织学检查显示,卵巢肿瘤为伴有少量性索成分的纤维瘤。
绝经后女性出现高雌激素状态的临床表现应引起医生对该实体的怀疑。此外,对卵巢纤维瘤进行全面评估有助于检测肿瘤内的少量性索成分,从而为更好地评估这些肿瘤的发病机制和临床行为奠定基础。由于高雌激素血症可能易患子宫内膜癌,因此应对患者进行密切随访。