Shono Takeshi, Kondo Tsuyoshi, Suita Sachiyo
Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
J Pediatr Urol. 2006 Oct;2(5):464-7. doi: 10.1016/j.jpurol.2005.11.004. Epub 2006 Jan 30.
In order to investigate the effect of location on the development of ectopic testes, the relationship between the degree of degenerative change in ectopic testes and their original position was examined in rat models of cryptorchidism.
Unilateral ectopic testes were created by excising the future scrotal skin on either the right or left side in newborn rats. At 60 days of age, the position of the testes was examined, the testicular weight and seminiferous tubular diameter (STD) were measured, and spermatogenesis was evaluated using the Johnsen score.
All the rats showed maldescended testes on the operated side, with the testes descending into the superficial inguinal pouch, the perineum or the transverse contralateral scrotum. The testicular weight, STD and Johnsen score were all significantly lower for the superficial inguinal testes than for either the perineal or contralateral scrotal testes.
These findings suggest that the degree of testicular degeneration depends on the position of the ectopic testes; the higher the testicular location, the greater the histological changes.
为了研究位置对隐睾发育的影响，在隐睾大鼠模型中，研究隐睾退变程度与其原始位置之间的关系。
通过切除新生大鼠右侧或左侧未来阴囊皮肤来制造单侧隐睾。在60日龄时，检查睾丸位置，测量睾丸重量和生精小管直径（STD），并使用约翰森评分评估精子发生情况。
所有大鼠手术侧睾丸均下降不全，睾丸降至腹股沟浅袋、会阴或对侧阴囊横部。腹股沟浅部睾丸的睾丸重量、STD和约翰森评分均显著低于会阴或对侧阴囊睾丸。
这些发现表明，睾丸退变程度取决于隐睾的位置；睾丸位置越高，组织学变化越大。
