Schober Justine M
Department of Pediatric Urology, Hamot Medical Center, Erie, PA, USA.
J Pediatr Urol. 2007 Jun;3(3):167-70. doi: 10.1016/j.jpurol.2006.07.010. Epub 2006 Nov 7.
Cancer of the neovagina has been documented, and found to occur at younger ages than cancer of the native vagina. A review of the world literature was performed to evaluate risk based on type of tissue used for replacement or reconstruction of the vagina, as well as signs and symptoms of tumor occurrence and follow-up possibilities for early detection/screening for cancer and precancerous changes.
Comprehensive review of relevant published literature.
Creation of a neovagina is infrequently performed with no established follow-up pattern. Neovaginal construction uses a variety of tissues: bowel, skin graft, vulvar skin flaps, rectus abdominus (myocutaneous) flaps, inverted penile skin. When exogenous tissue is used, tissue dysplasia can be expected because the tissue is suddenly subjected to new contacts/stresses. Pathological criteria of abnormality in epithelium transplanted to a vaginal location are not well established. Case reports suggest that squamous cell cancers occur in skin-graft vaginal constructions and adenocarcinomas occur in vaginas constructed of bowel. Clear or bloody discharge and postcoital bleeding are the most frequent first symptoms. Endoscopy and biopsy are needed for diagnosis.
Although considered rare, many cases of cancer of the neovagina are documented in the literature. Careful follow up of patients who have undergone neovagina construction is important.
已记录到新阴道癌的发生，且发现其发病年龄比原生阴道癌更小。对世界文献进行综述，以评估基于用于阴道置换或重建的组织类型的风险，以及肿瘤发生的体征和症状，以及癌症和癌前病变早期检测/筛查的随访可能性。
对相关已发表文献进行全面综述。
新阴道的创建很少进行，且没有既定的随访模式。新阴道构建使用多种组织：肠道、皮肤移植、外阴皮瓣、腹直肌（肌皮）瓣、倒置阴茎皮肤。当使用外源组织时，由于组织突然受到新的接触/压力，可能会出现组织发育异常。移植到阴道部位的上皮异常的病理标准尚未确立。病例报告表明，鳞状细胞癌发生在皮肤移植阴道构建中，腺癌发生在由肠道构建的阴道中。清亮或血性分泌物和性交后出血是最常见的首发症状。诊断需要内镜检查和活检。
尽管新阴道癌被认为罕见，但文献中记录了许多病例。对接受新阴道构建的患者进行仔细随访很重要。
