眶周坏死性黄色瘤与Ⅰ期多发性骨髓瘤。磁共振成像记录的超微结构及对脉冲地塞米松的反应

Periorbital necrobiotic xanthogranuloma and stage I multiple myeloma. Ultrastructure and response to pulsed dexamethasone documented by magnetic resonance imaging.

作者信息

Plotnick H, Taniguchi Y, Hashimoto K, Negendank W, Tranchida L

机构信息

Department of Dermatology, Wayne State University School of Medicine, Detroit, MI 48201.

出版信息

J Am Acad Dermatol. 1991 Aug;25(2 Pt 2):373-7. doi: 10.1016/0190-9622(91)70208-j.

DOI:10.1016/0190-9622(91)70208-j

PMID:1894775

Abstract

We observed a 40-year-old woman with necrobiotic xanthogranuloma from the inception of indurated eyelid and periorbital infiltrates and concurrent stage I multiple myeloma to resolution of infiltrates in skin and bone marrow after pulsed high-dose oral dexamethasone therapy. Ultrastructural studies revealed lipid vacuoles in epidermal keratinocytes, in dermal histiocytic macrophages, and in vascular and lymphatic endothelial cells. The presence of lipid vacuoles in epidermal keratinocytes has not been reported previously in xanthogranuloma.

摘要

我们观察了一名40岁患有渐进性坏死性黄色肉芽肿的女性，从硬结性眼睑和眶周浸润开始，同时伴有I期多发性骨髓瘤，到脉冲高剂量口服地塞米松治疗后皮肤和骨髓浸润消退。超微结构研究显示，在表皮角质形成细胞、真皮组织细胞巨噬细胞以及血管和淋巴管内皮细胞中存在脂质空泡。表皮角质形成细胞中脂质空泡的存在在黄色肉芽肿中此前尚未见报道。