Cao Lihuan, Wang Zhenghan, Yang Xianmei, Xie Li, Yu Long
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China.
FEBS Lett. 2008 Nov 12;582(27):3817-22. doi: 10.1016/j.febslet.2008.09.058. Epub 2008 Oct 21.
BIR domain and its containing proteins play critical roles in cell apoptosis and cell division. Here several lines of novelty were revealed based on a comprehensive evolutionary analysis of BIR domains in 11 representative organisms. First, the type II BIR domains in Survivin and Bruce showed more conservation compared with the type I BIR domains in the inhibitors of apoptosis proteins (IAPs). Second, cIAP was derived from a XIAP duplicate and emerged just after the divergence of invertebrates and vertebrates. Third, the three BIR domains of NAIP displayed significantly elevated evolutionary rates compared with the BIR domains in other IAPs.
BIR结构域及其包含的蛋白质在细胞凋亡和细胞分裂中发挥着关键作用。基于对11种代表性生物中BIR结构域的全面进化分析，揭示了几个新特点。首先，与凋亡抑制蛋白（IAPs）中的I型BIR结构域相比，Survivin和Bruce中的II型BIR结构域表现出更高的保守性。其次，cIAP源自XIAP的一个复制体，在无脊椎动物和脊椎动物分化后出现。第三，与其他IAPs中的BIR结构域相比，NAIP的三个BIR结构域显示出显著提高的进化速率。
