Rathinam Chozhavendan, Flavell Richard A
Yale University School of Medicine, USA.
Blood. 2008 Nov 1;112(9):3534-5. doi: 10.1182/blood-2008-07-167759.
For several years, the lineage differentiation program of HSCs was believed to be well organized and unidirectional. However, data from recent studies question the commitment of lineage-restricted progenitors to a single lineage. Now, interesting work by Welner and colleagues presented in this issue of suggests that the lineage differentiation pathways may be more complicated than initially thought.
多年来,人们一直认为造血干细胞的谱系分化程序是组织良好且单向的。然而,近期研究的数据对谱系受限祖细胞向单一谱系的定向分化提出了质疑。现在,韦尔纳及其同事在本期发表的有趣研究表明,谱系分化途径可能比最初认为的更为复杂。