Shortman Ken, Naik Shalin H
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.
Nat Rev Immunol. 2007 Jan;7(1):19-30. doi: 10.1038/nri1996. Epub 2006 Dec 15.
The developmental pathways that lead to the production of antigen-presenting dendritic cells (DCs) are beginning to be understood. These are the last of the pathways of haematopoiesis to be mapped. The existence of many specialized subtypes of DC has complicated this endeavour, as has the need to distinguish the DCs formed in steady state from those produced during an inflammatory response. Here we review studies that lead to the concept that different types of DC develop through different branches of haematopoietic pathways that involve different immediate precursor cells. Furthermore, these studies show that many individual tissues generate their own DCs locally, from a reservoir of immediate DC precursors, rather than depending on a continuous flux of DCs from the bone marrow.
导致抗原呈递树突状细胞（DCs）产生的发育途径正逐渐被人们所了解。这些是造血过程中最后一批被绘制出来的途径。DC存在许多特殊亚型，这使得这项工作变得复杂，而且需要区分稳态下形成的DC与炎症反应期间产生的DC。在这里，我们回顾了一些研究，这些研究得出了这样一个概念：不同类型的DC通过造血途径的不同分支发育而来，这些分支涉及不同的直接前体细胞。此外，这些研究表明，许多个体组织从直接DC前体细胞库中在局部产生自身的DC，而不是依赖于来自骨髓的DC持续流入。
