Pryce D W, McFarlane R J
North West Cancer Research Fund Institute, College of Natural Sciences, University of Wales Bangor, Memorial Building, Bangor, Gwynedd, UK.
Genome Dyn. 2009;5:1-13. doi: 10.1159/000166614.
Meiotic recombination predominantly occurs at genomic loci referred to as recombination hotspots. The fission yeast, Schizosaccharomyces pombe, has proved to be an excellent model organism in which to study details of the molecular basis of meiotic recombination hotspot activation. S. pombe has a number of different classes of meiotic hotspots, indicating that a single pathway does not confer hotspot activity throughout the genome. The M26-related hotspots are a particularly well characterised group of hotspots and details of the molecular activation of M26-related hotspots are now coming to light. Moreover, genome-wide DNA array analysis has been applied to the question of meiotic recombination in this organism and we are now starting to get a picture of recombination hotspot distribution on a genome-wide scale.
减数分裂重组主要发生在被称为重组热点的基因组位点。裂殖酵母（粟酒裂殖酵母）已被证明是一种优秀的模式生物，可用于研究减数分裂重组热点激活分子基础的细节。粟酒裂殖酵母有多种不同类型的减数分裂热点，这表明单一途径并不能赋予全基因组的热点活性。与M26相关的热点是一组特征特别明确的热点，现在M26相关热点分子激活的细节正在被揭示。此外，全基因组DNA阵列分析已应用于该生物体减数分裂重组的问题，我们现在开始了解全基因组范围内重组热点的分布情况。
