多杀巴斯德菌毒素活性位点处的组氨酸残基
Histidine Residues at the Active Site of the Pasteurella multocida Toxin.
作者信息
Pullinger Gillian D, Lax Alistair J
机构信息
King's College London, Dental Institute, Department of Microbiology, London SE1 9RT, UK.
出版信息
Open Biochem J. 2007;1:7-11. doi: 10.2174/1874091X00701010007. Epub 2007 Jun 15.
Abstract
We have investigated histidine residues near the active site of the mitogenic Pasteurella multocida toxin. Mutation of H1202 or H1228 had little effect, while the effect of mutation on H1223 depended on the amino acid substituted. Mutation of H1205 caused complete loss of activity, indicating its importance in PMT activity.
摘要
我们研究了促有丝分裂多杀巴斯德氏菌毒素活性位点附近的组氨酸残基。H1202或H1228的突变影响很小，而H1223突变的影响则取决于所取代的氨基酸。H1205的突变导致活性完全丧失，表明其在多杀巴斯德氏菌毒素活性中具有重要作用。
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