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[单核细胞增生李斯特菌:孕妇感染率上升报告及文献综述]

[Listeria monocytogenes: report of a rise in pregnant women and literature review].

作者信息

Noriega R L Miguel, Ibáñez V Sebastián, González A Patricia, Yamamoto C Masami, Astudillo D Julio, González V Marcelo, Riveros K Rodrigo, Lira C Fernando, Marcotti S Alejandra, Pérez G Jorge, Thompson M Luis, Daza P M Francisca, Espinosa I Maximiliano, Pinochet V Constanza, Vial C Pablo A

机构信息

Unidad Infectología, Departamento Medicina, Clínica Alemana, Santiago, Chile.

出版信息

Rev Chilena Infectol. 2008 Oct;25(5):342-9. Epub 2008 Oct 1.

Abstract

Listeria monocytogenes, rare pathogen in the general population, causes serious infections in patients at the extreme ages of life, pregnant woman, and those with immunosuppression. The clinical manifestations are essential to suspect the disease in patients at risk, allowing an early prescription of antimicrobial therapy, before the results of the cultures are available. Clinical course and prognosis depends on how early treatment is started and, in pregnant women, the gestational age. In Clínica Alemana, at Santiago, we detected a 15 fold rate rise of neonatal listeriosis between year 2007 and 2008. Ten cases were diagnosed between January and July 2008 and the seven cases occurring in pregnant women are reported here. All these patients were in their first pregnancy, which could be associated with similar lifestyle and food habits. Considering this new epidemiological scenario, it is important to educate the population, and to conduct an epidemiological study in order to determine the national situation of Listeria monocytogenes infection.

摘要

单核细胞增生李斯特菌在普通人群中是罕见病原体,但在高龄患者、孕妇及免疫功能低下者中可引发严重感染。临床表现对于怀疑高危患者患有该病至关重要,以便在培养结果出来之前尽早开具抗菌治疗药物。临床病程和预后取决于治疗开始的时间早晚,对于孕妇而言,还取决于孕周。在圣地亚哥的阿莱马纳诊所,我们发现2007年至2008年期间新生儿李斯特菌病发病率上升了15倍。2008年1月至7月诊断出10例病例,本文报告了其中7例发生在孕妇身上的病例。所有这些患者均为初产妇,这可能与相似的生活方式和饮食习惯有关。鉴于这种新的流行病学情况,对公众进行教育并开展流行病学研究以确定全国单核细胞增生李斯特菌感染情况非常重要。

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