Shingel Kirill I, Roberge Christophe, Zabeida Oleg, Robert Marielle, Klemberg-Sapieha Jolanta E
Bioartificial Gel Technologies (BAGTECH) Inc., 400 De Maisonneuve Ouest, Suite 1156, Montreal , QC, Canada, H3A 1L4.
J Mater Sci Mater Med. 2009 Mar;20(3):681-9. doi: 10.1007/s10856-008-3613-0. Epub 2008 Oct 24.
A series of the solid emulsion gels with the oil volume fraction in the range of 0-50% were synthesized through a polycondensation reaction between activated p-nitrophenyl carbonate poly(ethylene glycol) and protein-stabilized oil-in-water emulsions. The resultant structures were investigated in terms of swelling behavior, composition, morphology, mechanical and skin hydration properties. Solid emulsions gels share the properties of both hydrogel and emulsion. Similar to the classical hydrogel, the SEG swells in water up to equilibrium swelling degree, which decreases as the oil volume fraction increases, and comprises immobilized drops of protein-stabilized oil. The impregnation of the oil phase is found to reduce tensile stiffness of the material, but improves material's extensibility. The mechanical properties of the constructs (Young moduli in the range of 9-15 kPa and the elongation at break of 120-220%) are interpreted according to the "rule of elasticity mixture" that considers the elasticity of the composite material to be a sum of the contributions from individual components, i.e. hydrogel and dispersed oil drops. An idealized model that takes into account the history of the material preparation has been proposed to explain the improved extensibility of the constructs. The results of the mechanical tests, equilibrium swelling, and the skin hydration effect of the solid emulsion gels in vivo are discussed from the perspective of the biomedical applications of the solid emulsion gels, in particular, for the transdermal delivery of hydrophilic and lipophilic drugs.
通过活化对硝基苯基碳酸酯聚乙二醇与蛋白质稳定的水包油乳液之间的缩聚反应，合成了一系列油体积分数在0 - 50%范围内的固体乳液凝胶。从溶胀行为、组成、形态、力学和皮肤水合性能等方面对所得结构进行了研究。固体乳液凝胶兼具水凝胶和乳液的特性。与经典水凝胶类似，固体乳液凝胶在水中溶胀至平衡溶胀度，该溶胀度随油体积分数的增加而降低，且包含固定化的蛋白质稳定油滴。发现油相的浸渍会降低材料的拉伸刚度，但会提高材料的延展性。根据“弹性混合规则”解释了构建体的力学性能（杨氏模量在9 - 15 kPa范围内，断裂伸长率在120 - 220%之间），该规则认为复合材料的弹性是各个组分（即水凝胶和分散油滴）贡献的总和。为了解释构建体延展性的提高，提出了一个考虑材料制备历史的理想化模型。从固体乳液凝胶的生物医学应用角度，特别是对于亲水性和亲脂性药物的透皮递送，讨论了固体乳液凝胶在体内的力学测试、平衡溶胀和皮肤水合作用的结果。
