Fujishiro Takashi, Kojima Takayoshi
Department of Ophthalmology, Saitama Red Cross Hospital, Japan.
Nippon Ganka Gakkai Zasshi. 2008 Oct;112(10):847-54.
The prognosis after surgical treatment (local resection or enucleation) of uveal malignant melanoma was investigated.
Twenty-nine patients with uveal malignant melanoma were operated on from August, 1989 to December, 2005. We evaluated the prognosis of the cases according to the operative method (local resection or enucleation), size of tumors, histological types, and presence of scleral invasion.
14 patients underwent local resection and 15 patients underwent enucleation of the eyeball. The five year survival rate was 100% in the case of local resection, and 66% in the case of enucleation. More patients who had large tumors died than patients who had small tumors. The five year survival rate was 100% in spindle A, mixed, and epithelioid type, and 69% in spindle B type. Five year survival rate was 67% in the patients who had scleral invasion, and 92% in the patients who did not have scleral invasion.
In our series, local resection did not worsen the prognosis of the cases of choroidal malignant melanoma compared with the case of enucleation.
研究葡萄膜恶性黑色素瘤手术治疗(局部切除或摘除)后的预后情况。
1989年8月至2005年12月期间,对29例葡萄膜恶性黑色素瘤患者进行了手术。我们根据手术方式(局部切除或摘除)、肿瘤大小、组织学类型以及巩膜侵犯情况对病例的预后进行了评估。
14例患者接受了局部切除,15例患者接受了眼球摘除。局部切除病例的五年生存率为100%,眼球摘除病例的五年生存率为66%。肿瘤大的患者死亡人数多于肿瘤小的患者。梭形A、混合型和上皮样型的五年生存率为100%,梭形B型为69%。有巩膜侵犯的患者五年生存率为67%,无巩膜侵犯的患者五年生存率为92%。
在我们的系列研究中,与眼球摘除相比,局部切除并未使脉络膜恶性黑色素瘤病例的预后变差。