Mikuz G, Loewit K, Herbst M
Virchows Arch B Cell Pathol. 1975 Dec 19;19(4):359-68.
Adrenal-like lipoid-rich Leydig cells, which could be found in a cryptorchid testis, were investigated by light and electronmicroscopy. There were nodular and diffuse proliferation of these adrenal-like cells in the interstitium of the testis. Electronmicroscopically these cells are fasciculated and characterized by large liposomes, many tubulovesicular mitochondria, and a large smooth endoplasmatic reticulum. But the presence of crystals of Reinke in these cells underlined their relationship to Leydig cells. The clinical history of this case is characterised by an extreme adipositas (167 kg) and high urinary estrogenexcretion. This excretion could be suppressed with dexamethasone and stimulated with HCG. After orchiectomy estrogen excretion decreased for 4 months and then increased again, after ACTH stimulation performed by reason of adrenal insufficiency. At this time there is no evidence of adrenal tumor; in the contralateral, scrotal testis, spermiogenesis and Leydig cells are without pathologic changes as revealed by biopsy.
对在隐睾中发现的类肾上腺富含脂质的睾丸间质细胞进行了光镜和电镜研究。在睾丸间质中，这些类肾上腺细胞呈结节状和弥漫性增生。电镜下，这些细胞成束状排列，其特征为有大量脂质体、许多管状泡状线粒体和一个大的滑面内质网。但这些细胞中存在雷氏晶体，突出了它们与睾丸间质细胞的关系。该病例的临床病史表现为极度肥胖（167千克）和高尿雌激素排泄。这种排泄可被地塞米松抑制，被人绒毛膜促性腺激素刺激。睾丸切除术后，雌激素排泄减少了4个月，然后由于肾上腺功能不全进行促肾上腺皮质激素刺激后又再次增加。此时没有肾上腺肿瘤的证据；对侧阴囊内睾丸的活检显示，精子发生和睾丸间质细胞无病理变化。
