J Intern Med. 1991 Sep;230(3):233-7. doi: 10.1111/j.1365-2796.1991.tb00436.x.
A total of 5778 patients with suspected acute myocardial infarction were randomized to early intravenous metoprolol followed by oral treatment for 15 d, or to placebo. Thereafter, the two groups were treated similarly. During a 1-year follow-up period the mortality in patients who were randomized to early metoprolol was 10.6% compared to 10.7% for placebo (P greater than 0.2). Among patients with a higher risk of death, the tendency towards a reduced mortality in the metoprolol group that was observed after 15 d remained similar after 1 year. It is concluded that early intervention with metoprolol in suspected acute myocardial infarction did not improve the long-term prognosis compared to placebo treatment.
共有5778例疑似急性心肌梗死患者被随机分为两组，一组早期静脉注射美托洛尔，随后口服治疗15天，另一组给予安慰剂。此后，两组接受相似的治疗。在1年的随访期内，随机接受早期美托洛尔治疗的患者死亡率为10.6%，而安慰剂组为10.7%（P>0.2）。在死亡风险较高的患者中，美托洛尔组在15天后观察到的死亡率降低趋势在1年后仍然相似。得出的结论是，与安慰剂治疗相比，在疑似急性心肌梗死中早期使用美托洛尔进行干预并不能改善长期预后。
