编码两种野生型麻疹病毒株基质蛋白的基因的核苷酸序列。
Nucleotide sequence of the genes encoding the matrix protein of two wild-type measles virus strains.
作者信息
Baczko K, Brinckmann U, Pardowitz I, Rima B K, ter Meulen V
机构信息
Institute of Virology, University of Würzburg, Germany.
出版信息
J Gen Virol. 1991 Sep;72 ( Pt 9):2279-82. doi: 10.1099/0022-1317-72-9-2279.
The nucleotide sequences of the matrix protein (M) genes of two wild-type measles virus (MV) isolates (JM and CM) have been determined and shown to differ in 56 positions; 31 of these differences are located in the non-coding region and 25 in the coding region of the gene. Most (80%) of the mutations in the coding region are changes to the third base of a codon. A maximum parsimony analysis of the available M gene nucleotide sequences allowed the construction of a tree with at least three lineages or subtypes. One wild-type strain (JM) was very similar to a subacute sclerosing panencephalitis virus strain (case B); the second wild-type strain, CM, showed nucleotide sequence similarity with MV from a case of measles inclusion body encephalitis. Both wild-type virus sequences are distinct from those so far determined for vaccine strains.
已测定两种野生型麻疹病毒（MV）分离株（JM和CM）的基质蛋白（M）基因的核苷酸序列，结果显示它们在56个位置存在差异；其中31个差异位于基因的非编码区，25个位于编码区。编码区的大多数（80%）突变是密码子第三个碱基的变化。对可用的M基因核苷酸序列进行的最大简约分析允许构建一棵至少有三个谱系或亚型的树。一种野生型毒株（JM）与一种亚急性硬化性全脑炎病毒毒株（病例B）非常相似；第二种野生型毒株CM与一例麻疹包涵体脑炎患者的麻疹病毒显示出核苷酸序列相似性。两种野生型病毒序列均与迄今测定的疫苗株序列不同。
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