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评估手术适应性:普通外科患者中问卷调查、递增式往返步行测试和心肺运动试验的比较

Assessing fitness for surgery: a comparison of questionnaire, incremental shuttle walk, and cardiopulmonary exercise testing in general surgical patients.

作者信息

Struthers R, Erasmus P, Holmes K, Warman P, Collingwood A, Sneyd J R

机构信息

Department of Anaesthesia, Derriford Hospital, Plymouth PL6 8DH, UK.

出版信息

Br J Anaesth. 2008 Dec;101(6):774-80. doi: 10.1093/bja/aen310. Epub 2008 Oct 25.

Abstract

BACKGROUND

Morbidity and mortality are higher in patients with poor preoperative cardiorespiratory reserve. This study aimed to ascertain fitness and therefore risk in elective patients, comparing three measures: Duke Activity Status Index (DASI) questionnaire, incremental shuttle walk test (ISWT), and cycle cardiopulmonary exercise testing (CPET). We looked for correlation between the measures and for thresholds on the questionnaire or shuttle test which could identify fit patients and render CPET unnecessary.

METHODS

A prospective cohort trial of 50 patients having intra-abdominal surgery. Each performed DASI, ISWT, and CPET during a single visit to the hospital.

RESULTS

There was a significant correlation between measured oxygen consumption and both ISWT and DASI. Receiver operator curve showed both the shuttle walk test and the DASI are sensitive and specific predictors of VO(2)peak >15 ml O(2) kg(-1) min(-1) and anaerobic threshold (AT) >11 ml O(2) kg(-1) min(-1). Thirty-two patients would be considered lower risk, having achieved both VO(2)peak and AT cut-offs. Setting an ISWT threshold of 360 m identified 13 of the lower risk patients [positive predictive value (PPV) 1.0, negative predictive value (NPV) 0.49]. Setting a DASI threshold score of 46 identified nine lower risk patients (PPV 1.0, NPV 0.44).

CONCLUSIONS

We found a significant correlation between the tests. However, many patients with poor questionnaire scores or shuttle walks had satisfactory CPET results. Hence, the ability of either simple test to determine risk in a heterogeneous surgical population is poor. CPET provides an objective measurement of cardiopulmonary fitness; however, evidence for this information improving patient outcome is limited and requires further research.

摘要

背景

术前心肺储备功能差的患者发病率和死亡率更高。本研究旨在确定择期手术患者的身体状况及风险,比较三种测量方法:杜克活动状态指数(DASI)问卷、递增往返步行试验(ISWT)和循环心肺运动试验(CPET)。我们寻找这些测量方法之间的相关性,以及问卷或往返试验中的阈值,以识别身体状况良好的患者,从而无需进行CPET。

方法

对50例接受腹部手术的患者进行前瞻性队列试验。每位患者在单次住院期间均进行了DASI、ISWT和CPET。

结果

测得的耗氧量与ISWT和DASI均存在显著相关性。受试者工作特征曲线显示,往返步行试验和DASI都是预测VO₂峰值>15 ml O₂ kg⁻¹ min⁻¹和无氧阈(AT)>11 ml O₂ kg⁻¹ min⁻¹的敏感且特异的指标。32例患者VO₂峰值和AT均达到临界值,被认为风险较低。将ISWT阈值设定为360 m可识别出13例低风险患者[阳性预测值(PPV)为1.0,阴性预测值(NPV)为0.49]。将DASI阈值分数设定为46可识别出9例低风险患者(PPV 1.0,NPV 0.44)。

结论

我们发现这些测试之间存在显著相关性。然而,许多问卷得分低或往返步行结果差的患者CPET结果却令人满意。因此,这两种简单测试在异质性手术人群中确定风险的能力较差。CPET提供了心肺功能的客观测量;然而,这些信息改善患者预后的证据有限,需要进一步研究。

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