Delanaye Pierre, Cavalier Etienne, Radermecker Régis P, Paquot Nicolas, Depas Gisèle, Chapelle Jean-Paul, Scheen André J, Krzesinski Jean-Marie
Department of Nephrology, University of Liège, Liège, Belgium.
Nephron Clin Pract. 2008;110(3):c158-63. doi: 10.1159/000166607. Epub 2008 Oct 27.
Patients with anorexia nervosa (AN) are at a high risk of renal failure. Chronic kidney disease (CKD) is often missed in these patients because the serum creatinine is a poor marker of kidney function. We studied the utility of cystatin C to detect renal failure in this population.
Twenty-seven AN patients were studied. Glomerular filtration rates (GFR) were measured with the chromium-51- ethylenediaminetetraacetate ((51)Cr-EDTA) method. We compared the ability of creatinine and cystatin C to detect stage 3 CKD (GFR below 60 ml/min) by ROC curve analysis.
In this cohort, there is no correlation between GFR and serum creatinine, but there is a significant correlation between cystatin C and GFR. By ROC analysis, the cystatin C concentration is better than the serum creatinine concentration for the detection of stage 3 CKD (area under the curve of 0.86 vs. 0.61, p = 0.05).
Plasma cystatin C is better than serum creatinine in detecting stage 3 CKD in patients with AN.
神经性厌食症（AN）患者存在肾衰竭的高风险。这些患者常被漏诊慢性肾脏病（CKD），因为血清肌酐并非肾功能的良好指标。我们研究了胱抑素C在检测该人群肾衰竭中的效用。
对27例AN患者进行研究。采用铬-51-乙二胺四乙酸（（51）Cr-EDTA）法测量肾小球滤过率（GFR）。我们通过ROC曲线分析比较了肌酐和胱抑素C检测3期CKD（GFR低于60 ml/分钟）的能力。
在该队列中，GFR与血清肌酐之间无相关性，但胱抑素C与GFR之间存在显著相关性。通过ROC分析，胱抑素C浓度在检测3期CKD方面优于血清肌酐浓度（曲线下面积分别为0.86和0.61，p = 0.05）。
在检测AN患者的3期CKD方面，血浆胱抑素C优于血清肌酐。
