[细胞因子基因多态性与散发性女性乳腺癌相关恶病质的关联]

[Association of cytokine gene polymorphisms with cachexia related to sporadic female breast cancer].

作者信息

Li Fu-nian, Zhang Dian-liang, Li Yun-dong, Jiang Gui-mei

机构信息

Breast Disease Diagnosis and Treatment Centre, Hospital Affiliated to Qingdao University Medical College, Qingdao 266003, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2008 May 27;88(20):1402-4.

PMID:18953879

Abstract

OBJECTIVE

To investigate the relation of the frequency of tumor necrosis factor (TNF)-alpha - 308, TNF-beta + 252, IL-1 beta + 3954, and IL-10 - 1082 gene polymorphisms to female breast cancer.

METHODS

Peripheral blood samples were collected from 102 breast cancer patients with cachexia and 120 breast cancer patients without cachexia. Biallelic polymorphisms were performed by analyzing the incision enzyme-digested DNA fragment obtained using PCR.

RESULTS

The allele frequencies of TNF-beta + 252, IL-1 beta + 3954, and IL-10 -1082 in the patients with cachexia were comparable with those of the patients without cachexia (all P > 0.05). The patients with cachexia showed a significantly higher prevalence of TNF2 than the patients without cachexia (20.6 % vs 10.0 %, P = 0.027). Logistic regression analysis indicated TNF2 as a risk factor for cachexia in breast cancer ( OR = 2.333, 95% CI: 1.085-5.017).

CONCLUSION

TNF2 plays an important role in the susceptibility of cachexia in breast cancer.

摘要

目的

研究肿瘤坏死因子（TNF）-α -308、TNF-β +252、白细胞介素-1β（IL-1β）+3954和IL-10 -1082基因多态性频率与女性乳腺癌的关系。

方法

采集102例伴有恶病质的乳腺癌患者和120例无恶病质的乳腺癌患者的外周血样本。通过分析经PCR获得的经切口酶消化的DNA片段来检测双等位基因多态性。

结果

伴有恶病质的患者中TNF-β +252、IL-1β +3954和IL-10 -1082的等位基因频率与无恶病质的患者相当（均P>0.05）。伴有恶病质的患者中TNF2的患病率显著高于无恶病质的患者（20.6%对10.0%，P = 0.027）。Logistic回归分析表明TNF2是乳腺癌恶病质的一个危险因素（OR = 2.333，95%CI：1.085 - 5.017）。