Doweiko J P, Nompleggi D J
Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts.
JPEN J Parenter Enteral Nutr. 1991 Jul-Aug;15(4):476-83. doi: 10.1177/0148607191015004476.
The serum albumin level is one of several clinical parameters of the status of general health. There is a marked correlation between low albumin levels and the incidence of morbidity and mortality in hospitalized patients. Therefore, it is not surprising to find that hypoalbuminemia is a common finding among hospitalized patients. This results from alterations in the catabolic or anabolic rates, losses of albumin, or redistribution between the various fluid compartments of the body. Somewhat less well defined than the role of albumin as a prognostic indicator is its role in compounding pathophysiology. Hypoalbuminemia is known to be associated with delayed wound healing. The hypoalbuminemic state interferes with the normal functioning of the gastrointestinal tract. Qualitative changes in the albumin molecule which occur in renal disease may damage the nephron. Low serum albumin levels may adversely affect the coagulation system. Further investigation into the role of albumin in pathophysiology is warranted.
血清白蛋白水平是反映总体健康状况的若干临床参数之一。低白蛋白水平与住院患者的发病率和死亡率之间存在显著相关性。因此，低白蛋白血症在住院患者中很常见也就不足为奇了。这是由于分解代谢或合成代谢速率的改变、白蛋白的丢失或身体各体液间白蛋白的重新分布所致。与白蛋白作为预后指标的作用相比，其在病理生理过程中的作用定义得不太明确。已知低白蛋白血症与伤口愈合延迟有关。低白蛋白血症状态会干扰胃肠道的正常功能。肾病时白蛋白分子发生的质性变化可能会损害肾单位。低血清白蛋白水平可能会对凝血系统产生不利影响。有必要进一步研究白蛋白在病理生理过程中的作用。
