Qureshi H, Kamal S, Khan R A, Zuberi S J, Alam S E
PMRC Research Centre, Jinnah Postgraduate Medical Centre, Karachi.
J Pak Med Assoc. 1991 Jun;41(6):126-9.
Thirty-seven cases of portal hypertension with endoscopically proven oesophageal varices underwent liver biopsy to determine the etiology of portal hypertension. Of the total, 19 had cirrhosis and 18 idiopathic portal hypertension (IPH). Later all these patients underwent Tc99mSn colloid, static and dynamic scintigraphy of the liver and spleen. Ratios of the area and of the integral and slope of the integral for liver and spleen were calculated to see if any of these ratios can differentiate cirrhotics from IPH. Significant difference (P less than 0.001) was noted in the ratio of the area (L/S) in both patients and controls, but the ratios of the integral and the slope of the integral were not only significantly different (P less than 0.001) in the patients and controls but also in the two groups of patients (cirrhosis and IPH). The sensitivity of this test when compared with the histology was 58% for both cirrhosis and IPH but when compared with clinical diagnosis it was 76% for cirrhosis and 62% for idiopathic group. Therefore by adding the above mentioned test in the routine study of liver scintigraphy in patients with portal hypertension, further differentiation of cirrhotic group can be done from the idiopathic group.
37例经内镜证实有食管静脉曲张的门静脉高压患者接受了肝活检，以确定门静脉高压的病因。其中19例为肝硬化，18例为特发性门静脉高压（IPH）。随后，所有这些患者均接受了肝脏和脾脏的Tc99mSn胶体静态和动态闪烁扫描。计算肝脏和脾脏的面积比、积分比以及积分斜率比，以观察这些比值是否能够区分肝硬化患者和IPH患者。在患者和对照组中，面积比（L/S）均存在显著差异（P<0.001），而积分比和积分斜率比不仅在患者和对照组中存在显著差异（P<0.001），在两组患者（肝硬化和IPH）之间也存在显著差异。与组织学检查相比，该检查对肝硬化和IPH的敏感性均为58%，但与临床诊断相比，对肝硬化的敏感性为76%，对特发性组的敏感性为62%。因此，在门静脉高压患者的肝脏闪烁扫描常规检查中增加上述检查，可进一步区分肝硬化组和特发性组。
