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大动脉右位转位的产前诊断

Prenatal diagnosis of dextrotransposition of the great arteries.

作者信息

Hung Jeng-Hsiu, Huang Pi-Tao, Weng Zen-Chung, Chen Chih-Yao, Chao Kuan-Chong, Yang Ming-Jie, Hung Jamie

机构信息

Department of Obstetrics and Gynecology, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan, ROC.

出版信息

J Chin Med Assoc. 2008 Oct;71(10):541-5. doi: 10.1016/S1726-4901(08)70165-5.

Abstract

Dextrotransposition of the great arteries (DTGA) is a common cardiac cause of cyanosis in newborn infants that can cause acidosis and death within a short period of time unless there is a large atrial-level shunt or a patent ductus arteriosus. Here, we report a case of prenatal diagnosis of DTGA at 24+1 gestational weeks. In a tilted 4-chamber view, the pulmonary trunk branched to the left and the right pulmonary, with its root connected to the left ventricle outflow tract. In the short-axis view, the pulmonary trunk was shown to be parallel with the ascending aortic root. Cesarean section was performed due to the nonreassuring fetal status at 38+5 gestational weeks. The male neonate appeared to have mild cyanotic symptoms and weighed 3,108 g. Apgar scores were 8 and 9 at 1 and 5 minutes, respectively. Neonatal echocardiography was performed immediately after birth and the findings confirmed DTGA associated with atrial septal defect secundum. Postnatally, angiography confirmed the echocardiographic diagnosis of DTGA with a large atrial septal defect secundum and a large patent ductus arteriosus. Jatene arterial switch operation and atrial septal defect closure with Gore-Tex patch were performed. The neonate withstood the operation well and was discharged 27 days after birth weighing 2,950 g and in a stable condition. Prenatal diagnosis of DTGA can greatly aid to prepare the patient's family and the surgeon and significantly improve the outcome of complex heart disease in the neonatal period.

摘要

大动脉转位(DTGA)是新生儿期常见的导致发绀的心脏病因,若不存在大的心房水平分流或动脉导管未闭,可在短时间内导致酸中毒和死亡。在此,我们报告一例孕24 + 1周时产前诊断为DTGA的病例。在倾斜四腔心切面中,肺动脉干向左、右肺分支,其根部与左心室流出道相连。在短轴切面上,肺动脉干与升主动脉根部平行。因孕38 + 5周时胎儿状况不佳行剖宫产。男婴有轻度发绀症状,体重3108克。1分钟和5分钟时阿氏评分分别为8分和9分。出生后立即进行新生儿超声心动图检查,结果证实为DTGA合并继发孔型房间隔缺损。出生后,血管造影证实了超声心动图诊断的DTGA合并大的继发孔型房间隔缺损和大的动脉导管未闭。进行了Jatene动脉调转术及用戈尔特斯补片关闭房间隔缺损。新生儿手术耐受良好,出生27天后出院,体重2950克,情况稳定。DTGA的产前诊断可极大地帮助患者家属和外科医生做好准备,并显著改善新生儿期复杂心脏病的治疗效果。

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