马来西亚吉兰丹州转化生长因子-α与非综合征性唇裂伴或不伴腭裂或仅腭裂的关系
Transforming growth factor-alpha and nonsyndromic cleft lip with or without palate or cleft palate only in Kelantan, Malaysia.
作者信息
Rahman Roselinda Abdul, Ahmad Azlina, Rahman Zainal Ariff Abdul, Mokhtar Khairani Idah, Lah Nik Ahmad Shah Nik, Zilfalil Bin Alwi, Samsudin Ab Rani
机构信息
School of Dental Sciences, Universiti Sains Malaysia, 16150 Kota Bharu, Kelantan, Malaysia.
出版信息
Cleft Palate Craniofac J. 2008 Nov;45(6):583-6. doi: 10.1597/07-020.1. Epub 2008 Jan 6.
OBJECTIVE
To determine the frequency of the transforming growth factor-alpha (TGFalpha) Taq1 polymorphism in nonsyndromic cleft lip with or without cleft palate (CL+/-P) and cleft palate only (CP) in Kelantan, Malaysia.
SETTING
The study was conducted at the Combined Cleft Clinic and at the Human Genome Centre in Hospital Universiti Sains Malaysia in Kelantan, Malaysia.
DESIGN
We examined the C2/Taq1 variant of the TGFalpha gene in 46 patients with nonsyndromic CL+/-P or CP only and in 33 controls. The TGFalpha genotype frequencies in patients were compared with those in controls using the chi-square or Fisher exact test. DNA samples were obtained from peripheral blood.
RESULTS
No association was found between TGFalphaTaq1 polymorphism and CL+/-P or CP in this case-control study. In addition, no homozygosity for the rare allele C2 was noted in CL+/-P, CP, or the controls.
CONCLUSION
No evidence of TGFalphaTaq1 polymorphism was observed in association with CL+/-P and CP in this study.
目的
确定马来西亚吉兰丹州非综合征性唇裂伴或不伴腭裂（CL+/-P）及单纯腭裂（CP）患者中转化生长因子α（TGFα）Taq1多态性的频率。
地点
该研究在马来西亚吉兰丹州马来西亚理科大学医院的联合腭裂诊所及人类基因组中心开展。
设计
我们检测了46例仅患有非综合征性CL+/-P或CP的患者及33例对照者的TGFα基因C2/Taq1变异。采用卡方检验或Fisher精确检验比较患者与对照者的TGFα基因型频率。DNA样本取自外周血。
结果
在该病例对照研究中，未发现TGFαTaq1多态性与CL+/-P或CP之间存在关联。此外，在CL+/-P、CP患者或对照者中均未发现罕见等位基因C2的纯合性。
结论
本研究未观察到TGFαTaq1多态性与CL+/-P和CP相关的证据。
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