Miller J, Wallace D, Grieco M H, Frenkel R, Larsen K
Ann Allergy. 1977 Jul;39(1):12-7.
A double-blind comparison of 2 and 3 mg oral doses of carbuterol, a beta sympathomimetic drug with preferential selectivity for bronchial smooth muscle, was made with 25 and 35 mg doses of ephedrine sulfate over a six-month period in 26 patients with bronchial asthma. Spirometry was done before and three hours after administration of 3 mg of carbuterol or 35 mg of ephedrine sulfate at intervals of two weeks and one, four and six months. The data suggest a cumulative improvement in pulmonary function status with continued oral carbuterol use over the six-month period. However, the clinical effectiveness of the drug on pulmonary function was not clearly distinguishable from that of ephedrine in the present study.
在26例支气管哮喘患者中，对口服2毫克和3毫克的卡布特罗（一种对支气管平滑肌具有优先选择性的β拟交感神经药物）与25毫克和35毫克硫酸麻黄碱进行了为期六个月的双盲比较。在给药3毫克卡布特罗或35毫克硫酸麻黄碱之前以及给药后三小时进行肺活量测定，间隔时间分别为两周以及一、四和六个月。数据表明，在六个月的时间里持续口服卡布特罗可使肺功能状况得到累积改善。然而，在本研究中，该药物对肺功能的临床有效性与麻黄碱并无明显差异。
