James T D, Lyons H A
JAMA. 1979 Feb 16;241(7):704-5.
The bronchodilator effect of carbuterol hydrochloride, a new adrenergic agonist, was compared with that of ephedrine sulfate in 12 patients with bronchial asthma. A 2-mg dosage of carbuterol hydrochloride, three times daily, was used in comparison with a 25-mg dosage of ephedrine sulfate, three times daily. The drugs were orally administered for ten-day periods in a double-blind, randomized manner. After carbuterol therapy, the mean increases in forced expiratory volume in one second and midmaximal expiratory flow rate were significantly greater in a four-hour period than those noticed with ephedrine. A decrease in bronchodilator response to both drugs was noticed on the tenth day. No side effects were noticed with carbuterol at the aforementioned dosage. The results of our study indicate that carbuterol is a safer and more effective bronchodilator than ephedrine.
在12例支气管哮喘患者中，对新型肾上腺素能激动剂盐酸卡布特罗与硫酸麻黄碱的支气管扩张作用进行了比较。盐酸卡布特罗的用量为每日3次，每次2毫克，与硫酸麻黄碱每日3次，每次25毫克的用量进行对比。药物以双盲、随机方式口服给药，疗程为10天。卡布特罗治疗后，4小时内一秒用力呼气量和最大呼气中期流速的平均增加量显著大于麻黄碱治疗后的增加量。在第10天，观察到对两种药物的支气管扩张反应均有所下降。在上述剂量下，未观察到卡布特罗有副作用。我们的研究结果表明，与麻黄碱相比，卡布特罗是一种更安全、更有效的支气管扩张剂。
