Ohnishi Hirofumi, Saitoh Shigeyuki, Akasaka Hiroshi, Mitsumata Kaneto, Chiba Mizue, Furugen Makoto, Furukawa Tetsuaki, Mori Mitsuru, Shimamoto Kazuaki
Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo 060-8543, Japan.
Hypertens Res. 2008 Jul;31(7):1385-90. doi: 10.1291/hypres.31.1385.
Although abdominal obesity (AO) assessed by waist circumference (WC) is an important component of the metabolic syndrome (MetS), the usefulness of AO as a predictor of hypertension (HT) is not known. In this study, we investigated the incidence of HT in residents of two rural communities in Japan. The subjects were 187 men and 209 women selected from 712 residents who had undergone medical examinations in the towns of Tanno and Sobetsu, Hokkaido, in 1994 and 2002. Participants with HT in 1994 were excluded. Participants with AO were determined according to the WC criteria in the Japanese definition of MetS (> or = 85 cm for men, > or = 90 cm for women). The participants were divided into two groups: a non-AO group and an AO group. We compared the incidence of HT between the two groups and found a significantly higher incidence in the AO group. The results of logistic regression analysis showed that the relative risk of developing HT in individuals with AO was 2.33 (p = 0.017; 95% confidence interval [CI], 1.17-4.63) and that the risk per 1-cm increase in WC from 1994 to 2002 was 1.06 (p = 0.003; 95% CI, 1.02-1.10), both adjusted for several confounding factors. The results of this study suggest that, to prevent HT in Japanese, it is important to manage abdominal obesity and to monitor WC in individuals with or without abdominal obesity.
尽管通过腰围(WC)评估的腹型肥胖(AO)是代谢综合征(MetS)的重要组成部分,但AO作为高血压(HT)预测指标的效用尚不清楚。在本研究中,我们调查了日本两个农村社区居民中HT的发病率。研究对象为187名男性和209名女性,他们是从1994年和2002年在北海道胆沼町和曾别町接受体检的712名居民中挑选出来的。1994年患有HT的参与者被排除在外。根据日本MetS定义中的WC标准(男性≥85厘米,女性≥90厘米)确定患有AO的参与者。参与者被分为两组:非AO组和AO组。我们比较了两组之间HT的发病率,发现AO组的发病率显著更高。逻辑回归分析结果显示,患有AO的个体患HT的相对风险为2.33(p = 0.017;95%置信区间[CI],1.17 - 4.63),并且从1994年到2002年WC每增加1厘米的风险为1.06(p = 0.003;95% CI,1.02 - 1.10),两者均针对多个混杂因素进行了调整。本研究结果表明,为预防日本人患HT,管理腹型肥胖以及监测有或没有腹型肥胖个体的WC很重要。