Benharroch Daniel, Levy Amalia, Gopas Jacob, Sacks Martin
Department of Pathology, Soroka University Medical Center, Beer-Sheva, Israel.
Virchows Arch. 2008 Dec;453(6):611-6. doi: 10.1007/s00428-008-0683-9. Epub 2008 Oct 29.
Changes in the definition of lymphocyte-depleted classic Hodgkin lymphoma (LDcHL) have recently led to reclassification of many cases as other pleomorphic lymphomas. We have set out to identify LD cases in our cohort of cHL patients and determine their clinical and biological characteristics properties. We defined the morphologic picture of LDcHL according to selected criteria and determined how its features differ from those of other subtypes of cHL. Twelve of 201 cHL patients (5.9%) were diagnosed as showing LDcHL histology, a higher percentage of LDcHL than in most recent series. The LD cases were most often positive for Epstein-Barr virus and for sialyl-CD15. Defining the cases as either reticular (eight) or as diffuse fibrosis (three) variants was critical to the diagnostic approach. We conclude that LDcHL may be a neglected entity.
淋巴细胞消减型经典型霍奇金淋巴瘤（LDcHL）定义的改变最近导致许多病例被重新分类为其他多形性淋巴瘤。我们着手在我们的经典型霍奇金淋巴瘤（cHL）患者队列中识别LD病例，并确定其临床和生物学特征。我们根据选定标准定义了LDcHL的形态学表现，并确定其特征与其他cHL亚型的特征有何不同。201例cHL患者中有12例（5.9%）被诊断为具有LDcHL组织学表现，这一比例高于最近系列研究中的LDcHL比例。LD病例最常为EB病毒和唾液酸-CD15阳性。将病例定义为网状（8例）或弥漫性纤维化（3例）变体对诊断方法至关重要。我们得出结论，LDcHL可能是一个被忽视的实体。
