BMT Unit, Department of Hematology, Ospedale Careggi, Firenze, Italy.
Autoimmunity. 2008 Dec;41(8):570-6. doi: 10.1080/08916930802197776.
Hematopoietic stem cell transplantation has been utilized for the treatment of severe autoimmune diseases following the results of experimental studies and of coincidental diseases. While allogeneic transplantation is still being explored, autologous transplantation is the procedure most frequently utilized worldwide. The rationale for its utilization consists in its powerful immunosuppressive effect, but immune modulation polarized towards tolerance is also postulated. The mobilization of stem and progenitor cells from the marrow and the various conditioning regimens derive from the experience with hematologic malignancies. The greatest possible reduction of transplant-related-mortality and of the autoimmune aggression are being actively pursued. Here, the main procedural modalities will be analyzed and discussed.
造血干细胞移植已被用于治疗严重的自身免疫性疾病，这是基于实验研究和偶发疾病的结果。虽然异体移植仍在探索中，但自体移植是目前全球最常使用的方法。其应用的基本原理在于它具有强大的免疫抑制作用，但也有人提出免疫调节向耐受方向发展。从血液恶性肿瘤的经验中得出了从骨髓中动员干细胞和祖细胞以及各种调理方案。正在积极追求最大限度地降低移植相关死亡率和自身免疫攻击。在这里，将分析和讨论主要的程序模式。
