Scherer Ralf
Klinik für Anaesthesiologie und operative Intensivmedizin des Clemenshospitals, Münster.
Anasthesiol Intensivmed Notfallmed Schmerzther. 2008 Oct;43(10):692-701; quiz 702. doi: 10.1055/s-0028-1102988. Epub 2008 Oct 28.
In patients with brain edema the pathophysiology of the different forms of edema have to be considered to ensure the prompt, sensible and consistent use of the limited treatment modalities available. Brain edema may be classified into cytotoxic and vasogenic edema, these two types often coexist in one patient. Head elevation, hyperventilation, osmotic therapy and reduction of brain metabolism by sedation or hypothermia should be used closely monitoring ICP and blood pressure. In the future considering the autoregulatory capacity of the individual patient will possibly lead to a more effective action of the treatment modalities described. Further research will open new perspectives how aquaporines are involved in the genesis and mobilisation of brain edema.
对于脑水肿患者,必须考虑不同形式脑水肿的病理生理学,以确保合理、及时且一致地使用有限的可用治疗方法。脑水肿可分为细胞毒性水肿和血管源性水肿,这两种类型常并存于同一患者体内。应采用头部抬高、过度通气、渗透性治疗以及通过镇静或低温降低脑代谢,并密切监测颅内压和血压。未来,考虑个体患者的自动调节能力可能会使所述治疗方法发挥更有效的作用。进一步的研究将为水通道蛋白如何参与脑水肿的发生和消散开辟新的视角。