采用吸附溶出伏安法对双嘧达莫进行痕量测定。

Trace measurement of dipyridamole by adsorptive stripping voltammetry.

作者信息

Zeng X, Lin S, Hu N

机构信息

Department of Chemistry, Beijing Normal University, Beijing 100875, P. R. China.

出版信息

Talanta. 1993 Aug;40(8):1183-7. doi: 10.1016/0039-9140(93)80185-t.

DOI:10.1016/0039-9140(93)80185-t

PMID:18965766

Abstract

A sensitive adsorptive stripping voltammetric method for trace measurement of dipyridamole in alkaline solution is described. The method is based on the adsorptive accumulation of the drug at the hanging mercury drop electrode, followed by linear sweep voltammetric determination. The response is evaluated with respect to percentage of ethanol, preconcentration time and potential, and concentration of NaOH. The detection limit of 1.0 x 10(-9)M is obtained under optimized conditions with a 5-min preconcentration. Applicability to injection, tablets and urine analysis is illustrated.

摘要

本文描述了一种用于在碱性溶液中痕量测定双嘧达莫的灵敏吸附溶出伏安法。该方法基于药物在悬汞滴电极上的吸附富集，随后进行线性扫描伏安测定。考察了乙醇百分比、预富集时间和电位以及氢氧化钠浓度对响应的影响。在优化条件下，通过5分钟预富集可获得1.0×10⁻⁹M的检测限。说明了该方法在注射液、片剂和尿液分析中的适用性。