对苯二酚电极在氯仿中的研制。其在酸碱反应平衡常数测定及某些胺类药物电位滴定中的应用。

Development of quinhydrone electrode in chloroform. Application to the determination of equilibrium constants of acid-base reactions and potentiometric titration of some amine drugs.

作者信息

Pournaghi-Azar M H, Ordoukhanian J

机构信息

Electroanalytical Chemistry Laboratory, Faculty of Chemistry, University of Tabriz, Tabriz, Iran.

出版信息

Talanta. 1994 Apr;41(4):611-6. doi: 10.1016/0039-9140(93)e0035-c.

DOI:10.1016/0039-9140(93)e0035-c

PMID:18965971

Abstract

The optimum conditions for the functioning of quinhydrone electrode as acid indicator in chloroform was determined by voltammetric and potentiometric studies. This electrode was used for the determination of equilibrium constants of acid-base reactions and the potentiometric determination of the end point of acidimetric titrations of some amine drugs such as phenothiazinic derivatives in pharmaceutical preparations, after extraction into chloroform. The relative standard deviations of 20 mg of aliphatic amines, piperidine and piperazine substituted phenothiazines were 0.5, 0.7 and 1 % respectively.

摘要

通过伏安法和电位法研究确定了醌氢醌电极在氯仿中作为酸指示剂发挥作用的最佳条件。该电极用于测定酸碱反应的平衡常数，以及在药物制剂中的一些胺类药物（如吩噻嗪衍生物）经萃取进入氯仿后，对其进行酸量滴定终点的电位测定。20毫克脂肪胺、哌啶和哌嗪取代的吩噻嗪的相对标准偏差分别为0.5%、0.7%和1%。