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氧氟沙星 - 铜(II)配合物的分光光度法和极谱法研究

Spectrophotometric and polarographic investigation of the Ofloxacin-Cu(II) complexes.

作者信息

Kapetanović V, Milovanović L, Erceg M

出版信息

Talanta. 1996 Dec;43(12):2123-30. doi: 10.1016/S0039-9140(96)01999-6.

Abstract

By means of spectrophotometric methods it was found that ofloxacin reacts with copper(II) ions to form complexes with molar ratios of ofloxacin: Cu(II) of 1:1 at pH 4.00, 2:1 at pH 7.02 and 3:1 at pH 8.30. The stability constants of the complexes were determined. The formation of ofloxacin:Cu(II) 1:1 and 3:1 complexes was confirmed by a polarographic method and the corresponding overall stability constant was evaluated.

摘要

通过分光光度法发现,氧氟沙星与铜(II)离子反应形成配合物,在pH 4.00时氧氟沙星与铜(II)的摩尔比为1:1,在pH 7.02时为2:1,在pH 8.30时为3:1。测定了配合物的稳定常数。通过极谱法证实了氧氟沙星:铜(II)1:1和3:1配合物的形成,并评估了相应的总稳定常数。

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