Ghanem Ashraf
Department of Organic Chemistry, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland.
Talanta. 2005 Jun 15;66(5):1234-41. doi: 10.1016/j.talanta.2005.01.031.
Chirasil-beta-Dex containing an undecamethylene spacer (C11-Chirasil-Dex) was used as chiral stationary phase (CSP) in enantioselective gas chromatography (GC). The versatility of the new stationary phase in the simultaneous enantiomeric separation of a set of cyclopropane derivatives is demonstrated. The GC method provides information about the chemical yields of the cyclopropane products, enantioselectivity, substrate specifity, and catalytic activity of the chiral catalysts used in the intermolecular cyclopropanation of olefins and avoids time-consuming work-up procedures.
含有十一亚甲基间隔基的Chirasil-β-环糊精（C11-Chirasil-环糊精）被用作对映体选择性气相色谱（GC）中的手性固定相（CSP）。证明了这种新型固定相在同时对一组环丙烷衍生物进行对映体分离方面的多功能性。该气相色谱方法提供了有关环丙烷产物的化学产率、对映选择性、底物特异性以及用于烯烃分子内环丙烷化反应的手性催化剂的催化活性的信息，并且避免了耗时的后处理程序。
