El Tayeb Azza A, Abd El-Mottaleb Nashwa A, Abdel Aziz Ebtihal A
Department of Pediatric, Faculty of Medicine, Asyut University, Asyut, Egypt.
Biol Trace Elem Res. 2009 May;128(2):128-34. doi: 10.1007/s12011-008-8265-x. Epub 2008 Oct 30.
Secondary hyperparathyroidism and trace elements' metabolism disturbances are common, important, and treatable complications of chronic renal failure (CRF).The relation between parathyroid hormone (PTH) and some trace elements in CRF patients on hemodialysis is still not completely elucidated. The aim of this work is to determine the serum levels of PTH and the trace elements zinc (Zn) and magnesium (Mg) in children with CRF under hemodialysis. The relation between PTH and those trace elements will be investigated. The study included 24 children (15 males and nine females) with CRF on regular hemodialysis. Also, 15 healthy age-matched children were included as control group. Serum levels of PTH, zinc, and magnesium were determined in all cases and controls. PTH and magnesium levels in patients were significantly higher than controls. Serum zinc levels were significantly lower than controls. There was a significant negative correlation between serum levels of PTH and zinc as well as an insignificant negative correlation between PTH and serum magnesium in CRF patients. Elevated PTH may play a role in the pathogenesis of hypozincemia. However, this is another negative report on the relation between PTH and serum Mg in children with CRF.
继发性甲状旁腺功能亢进和微量元素代谢紊乱是慢性肾衰竭（CRF）常见、重要且可治疗的并发症。血液透析的CRF患者中甲状旁腺激素（PTH）与某些微量元素之间的关系仍未完全阐明。本研究的目的是测定血液透析的CRF患儿血清PTH水平以及微量元素锌（Zn）和镁（Mg）水平，并研究PTH与这些微量元素之间的关系。该研究纳入了24例接受定期血液透析的CRF患儿（15例男性，9例女性）。此外，纳入了15例年龄匹配的健康儿童作为对照组。测定了所有病例和对照组的血清PTH、锌和镁水平。患者的PTH和镁水平显著高于对照组，血清锌水平显著低于对照组。CRF患者血清PTH水平与锌之间存在显著负相关，PTH与血清镁之间存在不显著的负相关。PTH升高可能在低锌血症的发病机制中起作用。然而，这是关于CRF患儿PTH与血清Mg之间关系的又一负面报道。
