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癸酸氟奋乃静、口服盐酸氟奋乃静及安慰剂用于缓解期精神分裂症患者。I. 一年后的复发率

Fluphenazine decanoate, fluphenazine hydrochloride given orally, and placebo in remitted schizophrenics. I. Relapse rates after one year.

作者信息

Rifkin A, Quitkin F, Rabiner C J, Klein D F

出版信息

Arch Gen Psychiatry. 1977 Jan;34(1):43-7. doi: 10.1001/archpsyc.1977.01770130045004.

DOI:10.1001/archpsyc.1977.01770130045004
PMID:189724
Abstract

In a simple remitted, nonpsychotic schizophrenics, the relapse rate within one year was significantly higher for those patients taking placebo as opposed to those taking fluphenazine hydrochloride orally or fluphenazine decanoate. There were no differences in relapse rates between the two active drugs, but there were significantly more terminations due to toxicity from fluphenazine decanoate than from pluphenazine given orally, entirely due to the fact that in 35% of patients receiving fluphenazine decanoate, severe akinesia developed.

摘要

在单纯缓解期的非精神病性精神分裂症患者中,服用安慰剂的患者一年内的复发率显著高于口服盐酸氟奋乃静或氟奋乃静癸酸酯的患者。两种活性药物之间的复发率没有差异,但因氟奋乃静癸酸酯毒性导致的停药显著多于口服氟奋乃静,这完全是因为在接受氟奋乃静癸酸酯的患者中有35%出现了严重的运动不能。

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