一名年轻成人颊黏膜鳞状细胞癌患者，其有儿童期急性白血病异基因骨髓移植史。
Squamous cell carcinoma of the buccal mucosa in a young adult with history of allogeneic bone marrow transplantation for childhood acute leukemia.
作者信息
Tomihara Kei, Dehari Hironari, Yamaguchi Akira, Abe Masato, Miyazaki Akihiro, Nakamori Kenji, Hareyama Masato, Hiratsuka Hiroyoshi
机构信息
Department of Oral Surgery, Sapporo Medical University, Sapporo, Japan.
出版信息
Head Neck. 2009 Apr;31(4):565-8. doi: 10.1002/hed.20931.
BACKGROUND
Secondary cancers are severe complications in patients who have had allogeneic bone marrow transplantation for childhood leukemia. We describe here a case of squamous cell carcinoma (SCC) of the buccal mucosa in a young adult patient who had had allogeneic bone marrow transplantation for childhood acute leukemia.
METHODS AND RESULTS
The primary tumor was treated with interstitial brachytherapy, and lymph node metastasis was treated by supraomohyoid neck dissection. The patient had a history of acute lymphoblastic leukemia (ALL) at 11 years of age and had received an allogeneic bone marrow transplant from a female donor. Further investigation of the tissue specimens by fluorescent in situ hybridization (FISH) revealed that an XX chromosome pattern was dominant in the tumor region, and this suggested that donor-derived cells might affect carcinogenesis in the recipient.
CONCLUSIONS
This case presents an incidence of secondary oral cancer associated with allogeneic bone marrow transplantation.
背景
继发性癌症是儿童白血病患者接受异基因骨髓移植后的严重并发症。我们在此描述一例年轻成年患者颊黏膜鳞状细胞癌（SCC），该患者曾因儿童急性白血病接受异基因骨髓移植。
方法与结果
原发性肿瘤采用组织间近距离放射治疗，淋巴结转移采用肩胛舌骨上颈清扫术治疗。该患者11岁时曾患急性淋巴细胞白血病（ALL），并接受了来自女性供体的异基因骨髓移植。通过荧光原位杂交（FISH）对组织标本进行进一步研究发现，肿瘤区域以XX染色体模式为主，这表明供体来源的细胞可能影响受体的致癌过程。
结论
本病例呈现了与异基因骨髓移植相关的继发性口腔癌的发生率。
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