肝细胞癌中Tiam1的过表达预示着肝癌患者的预后不良。
Overexpression of Tiam1 in hepatocellular carcinomas predicts poor prognosis of HCC patients.
作者信息
Ding Yi, Chen Bin, Wang Shuang, Zhao Liang, Chen Juanzhi, Ding Yanqing, Chen Longhua, Luo Rongcheng
机构信息
Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, People's Republic of China.
出版信息
Int J Cancer. 2009 Feb 1;124(3):653-8. doi: 10.1002/ijc.23954.
Little research has been done to test the usefulness of T-lymphoma invasion and metastasis 1 (Tiam1) as a prognostic marker for hepatocellular carcinoma (HCC). In this study, we investigated Tiam1 expression and its prognostic value for HCC. HCC surgical tissue samples were taken from 152 HCC patients who had been followed up for 5 years. Overexpression of Tiam1 (Tiam1 2+ to 3+) was shown in 63.8% of the cases. The Tiam1 expression level did not correlate with any clinicopathological parameters. However, survival analysis showed that the Tiam1 overexpression group had a significantly shorter overall survival time than the Tiam1 downexpression group (p=0.008). Multivariate analysis showed that Tiam1 expression was a significant and independent prognostic parameter (p=0.042) for HCC patients. Tiam1 expression may be a novel and independent predictor for the prognosis of HCC patients.
关于检测T淋巴瘤侵袭转移蛋白1（Tiam1）作为肝细胞癌（HCC）预后标志物的有用性的研究很少。在本研究中，我们调查了Tiam1在HCC中的表达及其预后价值。从152例接受了5年随访的HCC患者中获取手术组织样本。63.8%的病例显示Tiam1过表达（Tiam1 2+至3+）。Tiam1表达水平与任何临床病理参数均无相关性。然而，生存分析显示，Tiam1过表达组的总生存时间明显短于Tiam1低表达组（p=0.008）。多变量分析显示，Tiam1表达是HCC患者的一个显著且独立的预后参数（p=0.042）。Tiam1表达可能是HCC患者预后的一个新的独立预测指标。
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