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SESN2与肝细胞癌的良好预后相关。

SESN2 correlates with advantageous prognosis in hepatocellular carcinoma.

作者信息

Chen Shaosen, Yan Weigang, Lang Weiya, Yu Jing, Xu Li, Xu Xinyu, Liu Yunlong, Bao Hongguang

机构信息

Department of Thoracic Surgery and Oncology, the No. 2 Affiliated Hospital of Qiqhar Medical University, Qiqhar, 161000, China.

Department of Oncology, the First Hospital of Qiqhar City, Qiqhar, 161000, China.

出版信息

Diagn Pathol. 2017 Jan 24;12(1):13. doi: 10.1186/s13000-016-0591-2.

DOI:10.1186/s13000-016-0591-2
PMID:28118855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5260065/
Abstract

BACKGROUND

SESN2 plays important roles in the regulation of cell survival, cell protection, and tumor suppression. However, the relationship between SESN2 expression and the clinicopathological attributes of hepatocellular carcinoma (HCC) is barely investigated.

METHODS

One-step quantitative reverse transcription PCR, Western blotting analysis in 15 fresh HCC tissues, and immunohistochemistry (IHC) analysis in a tissue microarray (TMA) containing 100 HCC cases were performed to examine SESN2 expression. Survival analyses by Cox regression method and Kaplan-Meier curve were performed to describe the overall survival of 100 HCC patients.

RESULTS

The SESN2 expression in HCC tissues declined dramatically compared with the corresponding noncancerous tissues, and SESN2 expression was remarkably associated with HBV infection (p = 0.019), HCV infection (p = 0.001), and lymph node metastasis (p = 0.033). Survival analysis further demonstrated that SESN2 expression could serve as an independent prognostic biomarker for overall survival in univariate (p = 0.001) and multivariate analyses (p = 0.003).

CONCLUSION

The data are the first to indicate that SESN2 might be a novel prognostic marker for HCC and that elevated SESN2 expression predicts advantageous outcomes in HCC patients.

摘要

背景

SESN2在细胞存活调控、细胞保护及肿瘤抑制中发挥重要作用。然而，SESN2表达与肝细胞癌（HCC）临床病理特征之间的关系鲜少被研究。

方法

采用一步定量逆转录PCR、对15例新鲜HCC组织进行蛋白质印迹分析以及对包含100例HCC病例的组织芯片（TMA）进行免疫组化（IHC）分析，以检测SESN2表达。采用Cox回归方法和Kaplan-Meier曲线进行生存分析，以描述100例HCC患者的总生存期。

结果

与相应的癌旁组织相比，HCC组织中的SESN2表达显著下降，且SESN2表达与乙肝病毒（HBV）感染（p = 0.019）、丙肝病毒（HCV）感染（p = 0.001）及淋巴结转移（p = 0.033）显著相关。生存分析进一步表明，在单因素分析（p = 0.001）和多因素分析（p = 0.003）中，SESN2表达可作为总生存期的独立预后生物标志物。

结论

这些数据首次表明，SESN2可能是HCC的一种新型预后标志物，且SESN2表达升高预示着HCC患者有较好的预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc45/5260065/d852becd9520/13000_2016_591_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc45/5260065/27eae73708e0/13000_2016_591_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc45/5260065/f10a59cb97fb/13000_2016_591_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc45/5260065/e518452c0209/13000_2016_591_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc45/5260065/d852becd9520/13000_2016_591_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc45/5260065/27eae73708e0/13000_2016_591_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc45/5260065/f10a59cb97fb/13000_2016_591_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc45/5260065/e518452c0209/13000_2016_591_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc45/5260065/d852becd9520/13000_2016_591_Fig4_HTML.jpg

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