Lee Jung Eun, Lee Sang Ju, Lee Hee Jung, Lee Ju Hee, Lee Kwang Hoon
Yonsei Star Skin & Laser Clinic, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 2008 Oct 31;49(5):851-2. doi: 10.3349/ymj.2008.49.5.851.
Epidermal growth factor has an important role in the regulation of proliferation and differentiation in epidermal keratinocytes, as well as in the survival, angiogenesis and metastasis of cancer cells. Cetuximab is a chimeric monoclonal antibody selective for the epidermal growth factor receptor that induces a broad range of cellular responses that enhance tumor sensitivity to radiotherapy and chemotherapeutic agents. However, it can cause adverse events in the patient including acneiform eruption, asthenia, abdominal pain and nausea/vomiting. We report a case of severe acneiform eruption induced by cetuximab in a 56-year-old man with colorectal cancer and liver metastases.
表皮生长因子在调节表皮角质形成细胞的增殖和分化以及癌细胞的存活、血管生成和转移中发挥着重要作用。西妥昔单抗是一种对表皮生长因子受体具有选择性的嵌合单克隆抗体，可诱导多种细胞反应，增强肿瘤对放疗和化疗药物的敏感性。然而，它会导致患者出现不良事件，包括痤疮样皮疹、乏力、腹痛和恶心/呕吐。我们报告了一例56岁患有结直肠癌和肝转移的男性患者因西妥昔单抗诱发严重痤疮样皮疹的病例。
