Lim Li-Anne, Chindasub Panida, Kitnarong Naris
University of New South Wales, Australia.
J Med Assoc Thai. 2008 Oct;91(10):1551-7.
To determine the surgical outcome of primary trabeculectomy with mitomycin C (MMC) and fornix-based conjunctival flap technique in Thai patients.
This retrospective review was conducted from the clinical records of all Thai glaucoma patients who underwent a primary trabeculectomy with MMC using a fornix-based conjunctival flap technique by or under supervision of one ophthalmologist (NK) between February 2004 and July 2006 at Siriraj Hospital, School of Medicine, Mahidol University, Bangkok, Thailand.
There were 69 eyes from 60 patients. Postoperatively, mean intraocular pressure (IOP) was significantly decreased from 26.1 +/- 11.7 mmHg to 11.7 +/- 4.4 mmHg (p < 0.001) and mean number of anti-glaucoma medication was significantly reduced from 3.9 +/- 0.7 to 0.3 +/- 0.9 (p < 0.001) at last visit. Sixty-seven eyes (96.8%) were considered as success. Eight eyes (11.6%) in this group needed topical anti-glaucoma medications. Two eyes (2.9%) were considered as failure. Mean follow-up period was 7.7 +/- 4.0 months. Complications included bleb leaking in 16 eyes, choroidal detachment in four eyes, and blebitis in two eyes. Seven eyes with leaking bleb resolved spontaneously.
Primary trabeculectomy with MMC using afornix-based conjunctival flap technique is effective as a treatment for Thai glaucoma patients. There is a high rate of success (96.8%) with the low rate of complication.
确定丝裂霉素C（MMC）小梁切除术联合穹窿部结膜瓣技术在泰国患者中的手术效果。
本回顾性研究通过泰国曼谷玛希隆大学医学院诗里拉吉医院一名眼科医生（NK）在2004年2月至2006年7月期间实施或指导实施的采用MMC小梁切除术联合穹窿部结膜瓣技术的所有泰国青光眼患者的临床记录进行。
60例患者共69只眼。术后，末次随访时平均眼压（IOP）从26.1±11.7 mmHg显著降至11.7±4.4 mmHg（p<0.001），平均抗青光眼药物数量从3.9±0.7显著降至0.3±0.9（p<0.001）。67只眼（96.8%）被视为手术成功。该组中有8只眼（11.6%）需要局部使用抗青光眼药物。2只眼（2.9%）被视为手术失败。平均随访时间为7.7±4.0个月。并发症包括16只眼的滤过泡渗漏、4只眼的脉络膜脱离和2只眼的滤过泡炎。7只滤过泡渗漏的眼自行愈合。
采用穹窿部结膜瓣技术的MMC小梁切除术对泰国青光眼患者是一种有效的治疗方法。成功率高（96.8%）且并发症发生率低。
