Department of Ophthalmology, Southampton University Hospital NHS Foundation Trust, Southampton, UK.
Department of Ophthalmology, Faculty of Medicine, Aswan University, Aswan, Egypt.
Korean J Ophthalmol. 2021 Aug;35(4):304-310. doi: 10.3341/kjo.2021.0044. Epub 2021 Jun 21.
This study aims to investigate the safety, efficacy and feasibility of sutureless trabeculectomy using a porous collagen matrix that contains a connected porous structure (Ologen) in the control of intraocular pressure (IOP) in glaucoma patients .
The study includes 25 eyes from 24 patients that met the inclusion criteria. All eyes underwent trabeculectomy with the Ologen implant that provides a space with a dynamic and physiological aqueous reservoir system. The operation was considered successful if IOP is <15 mmHg without need of IOP-lowering drops at 18 months of follow-up.
The target IOP was achieved in 21 out of the 25 eyes (84%), the remaining four eyes all had an IOP of 16 mmHg at 18 months. Short-term complications consisted of seven cases of bleb leakage treated with bandage contact lens and one case of mild choroidal effusion which resolved after observation alone.
We can conclude that this technique can provide safety, effectiveness and short learning curve for ophthalmology trainees with lower incidence of perioperative and postoperative complications. Further studies may be required to prove stability and long-term efficacy in management of glaucoma patients.
本研究旨在探讨使用含有连通多孔结构的多孔胶原基质（Ologen）进行无缝小梁切除术的安全性、有效性和可行性，以控制青光眼患者的眼内压（IOP）。
本研究纳入了符合纳入标准的 24 例患者的 25 只眼。所有眼均行 Ologen 植入物小梁切除术，该植入物提供了一个具有动态和生理房水储液系统的空间。如果在 18 个月的随访中，IOP<15mmHg 且无需使用降眼压滴注，则认为手术成功。
25 只眼中有 21 只（84%）达到了目标眼压，其余 4 只眼在 18 个月时的眼压均为 16mmHg。短期并发症包括 7 例眼泡漏，用绷带接触镜治疗，1 例轻度脉络膜积液，经单纯观察后缓解。
我们可以得出结论，这种技术可以为眼科培训生提供安全性、有效性和较短的学习曲线，同时降低围手术期和术后并发症的发生率。可能需要进一步的研究来证明在青光眼患者管理中的稳定性和长期疗效。
