Swamy Ravi, Embleton Nicholas, Hale Juliet
Newcastle Neonatal Service, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK.
Prenat Diagn. 2008 Nov;28(11):1048-51. doi: 10.1002/pd.2122.
The birth prevalence and malignant tumour recurrence of sacrococcygeal teratoma (SCT) have not been clearly defined. We conducted this study to determine the birth prevalence, prenatal detection rate, frequency of tumour recurrence and outcome of SCT in a population-based cohort.
Cases were identified from a population-based, regional database of congenital anomalies for the years 1985-2006. Prenatal diagnosis, management details, tumour recurrence and outcome were obtained from case records and cross linked with a regional oncology database.
There were 754,172 live births and 28 live born infants with SCT giving a birth prevalence of 1 per 27 000 live births. There was a prenatal diagnosis in 50% of cases. No cases presenting in the neonatal period had malignant tumour present at diagnosis or subsequent tumour recurrence. Nine (37.5%) of the survivors had chronic morbidities.
The birth prevalence of SCT was higher than that of previously reported. Infants who were live born and survived definitive surgical management had a good prognosis.
骶尾部畸胎瘤（SCT）的出生患病率和恶性肿瘤复发情况尚未明确界定。我们开展这项研究以确定基于人群队列中SCT的出生患病率、产前检出率、肿瘤复发频率及转归。
病例来自1985 - 2006年基于人群的区域性先天性异常数据库。从病例记录中获取产前诊断、治疗细节、肿瘤复发及转归情况，并与区域性肿瘤数据库进行交叉关联。
共有754,172例活产婴儿，28例患有SCT的活产婴儿，出生患病率为每27,000例活产婴儿中有1例。50%的病例有产前诊断。新生儿期就诊的病例在诊断时或随后肿瘤复发时均无恶性肿瘤。9名（37.5%）幸存者有慢性疾病。
SCT的出生患病率高于先前报道。经确定性手术治疗存活的婴儿预后良好。
