Suda T, Iwashita M, Sumitomo T, Nakano Y, Tozawa F, Demura H
Department of Medicine, Tokyo Women's Medical College, Japan.
Acta Endocrinol (Copenh). 1991 Aug;125(2):165-9. doi: 10.1530/acta.0.1250165.
CRH-binding protein was present in the amniotic fluid and in the umbilical cord plasma after 15 weeks and 24 weeks of pregnancy, respectively. The size of the CRH-binding protein was similar to that in the peripheral blood from normal subjects. The level of the binding of CRH-binding protein in the umbilical cord plasma during the third trimester of pregnancy was also similar to that in the peripheral blood of neonates and normal adult subjects. The binding of CRH-binding protein was temporarily decreased at 40 weeks of pregnancy. These results indicate that fetal CRH-binding protein seems to be produced at least in the second trimester of pregnancy.
促肾上腺皮质激素释放激素结合蛋白分别在妊娠15周和24周后的羊水和脐血浆中出现。促肾上腺皮质激素释放激素结合蛋白的大小与正常受试者外周血中的相似。妊娠晚期脐血浆中促肾上腺皮质激素释放激素结合蛋白的结合水平也与新生儿和正常成人受试者外周血中的相似。促肾上腺皮质激素释放激素结合蛋白的结合在妊娠40周时暂时降低。这些结果表明，胎儿促肾上腺皮质激素释放激素结合蛋白似乎至少在妊娠中期产生。
