DeLaurier A, Boyde A, Jackson B, Horton M A, Price J S
Bone and Mineral Centre, Department of Medicine, University College London, UK.
J Periodontal Res. 2009 Apr;44(2):248-57. doi: 10.1111/j.1600-0765.2008.01123.x. Epub 2008 Oct 7.
Domestic cats commonly suffer from external osteoclastic tooth resorption, a disease with many similarities to human multiple idiopathic root resorption. In both diseases, it is unclear whether anatomical features of the tooth surface are associated with a predisposition for resorptive lesions. The aim of the present study was to investigate the origin and progression of early feline osteoclastic resorptive lesions in teeth exhibiting no clinical signs of disease.
The entire surfaces of 138 teeth from 13 adult cats were analysed using back-scattered electron microscopy. The distribution of lesions was assessed by tooth type, location and between individuals.
Seventy-three (53%) teeth showed at least one resorptive lesion. Eleven (85%) cats had lesions, and there was a significant association between increasing age and incidence of resorptive lesions. The highest frequency occurred in mandibular molars (82%). On average, there were 3.5 lesions per tooth. Fifty-two (38%) teeth featured resorptive lesions at the cemento-enamel junction. Twenty-three per cent of teeth with resorptive lesions showed evidence of repair of lesions that was limited to the root surface. There was no evidence of repair of resorptive lesions at the cemento-enamel junction.
Resorption is prevalent without evidence of clinical disease, and occurred at younger ages than previously reported. It can initiate anywhere on the root surface, but lack of repair of lesions at the cemento-enamel junction indicates that mechanisms of replacement are absent or compromised in this region. Whereas resorption of the root may undergo repair, resorption at the cervix may progress to clinically evident lesions.
家猫常患外部破骨性牙齿吸收，这是一种与人类多发性特发性牙根吸收有许多相似之处的疾病。在这两种疾病中，牙齿表面的解剖特征是否与吸收性病变的易感性相关尚不清楚。本研究的目的是调查在无疾病临床症状的猫牙齿中早期破骨性吸收性病变的起源和进展。
使用背散射电子显微镜分析了13只成年猫的138颗牙齿的整个表面。通过牙齿类型、位置和个体之间评估病变的分布。
73颗（53%）牙齿至少有一处吸收性病变。11只（85%）猫有病变，吸收性病变的发生率与年龄增长之间存在显著关联。下颌磨牙的发生率最高（82%）。每颗牙齿平均有3.5处病变。52颗（38%）牙齿在牙骨质-釉质交界处有吸收性病变。23%有吸收性病变的牙齿显示病变仅限于牙根表面的修复迹象。在牙骨质-釉质交界处没有吸收性病变修复的证据。
吸收在无临床疾病证据的情况下普遍存在，且发生年龄比先前报道的要小。它可在牙根表面的任何部位起始，但牙骨质-釉质交界处病变缺乏修复表明该区域的替代机制不存在或受损。虽然牙根吸收可能会进行修复，但颈部吸收可能会发展为临床明显的病变。
