Rabbani Malik Anas, Habib Haseeb Bin, Siddiqui Bilal Karim, Tahir M Hammad, Ahmad Bushra, Murtaza Ghulam, Maria Qamaruddin, Ahmad Aasim
Department of Nephrology, The kidney Center, Post Graduate Training Institute Karachi, Pakistan.
Saudi J Kidney Dis Transpl. 2008 Nov;19(6):1009-14.
Acute renal failure (ARF) occurs commonly in developing countries. Our aim was to assess the etiologies and outcomes of ARF in a tertiary care hospital in Pakistan and compare them with data from developed and developing countries. All patients admitted to the Aga Khan University Hospital, Karachi from January 1991 to December 2000 fulfilling the criteria of acute renal failure were reviewed retrospectively. Acute renal failure for the purpose of this study was defined as persistent elevation of serum creatinine to above 2 mg/dL (177 umol/L) on two consecutive occasions despite correction of any abnormal hemodynamic or mechanical factors. We studied 898 patients fulfilling the criteria of ARF, 61% (551) were males, and the mean age was 53% +/- 17.6 (range 15-91) years. Medical causes accounted for (88%) of ARF cases and surgical causes for (11%). Majority of the patients had pre-renal ARF, and 5% had drug related ARF. The base line creatinine was 1.9 +/- 1.8 mg/dL, while 27% of the patients had pre-existing chronic kidney disease. The mean rise in creatinine was 7.18 +/- 3.8 mg/dL. We conclude that ARF resulted from pre-renal etiologies in majority of the patients and early recognition and management may improve the prognosis of these potentially preventable causes.
急性肾衰竭（ARF）在发展中国家很常见。我们的目的是评估巴基斯坦一家三级护理医院中ARF的病因和结局，并将其与发达国家和发展中国家的数据进行比较。对1991年1月至2000年12月入住卡拉奇阿迦汗大学医院且符合急性肾衰竭标准的所有患者进行了回顾性研究。本研究中，急性肾衰竭被定义为尽管纠正了任何异常的血流动力学或机械因素，但血清肌酐仍连续两次持续升高至2mg/dL（177μmol/L）以上。我们研究了898例符合ARF标准的患者，其中61%（551例）为男性，平均年龄为53±17.6岁（范围15 - 91岁）。ARF病例中，医学原因占88%，手术原因占11%。大多数患者为肾前性ARF，5%为药物相关性ARF。基线肌酐为1.9±1.8mg/dL，27%的患者已有慢性肾脏病。肌酐平均升高7.18±3.8mg/dL。我们得出结论，大多数患者ARF由肾前性病因引起，早期识别和处理可能改善这些潜在可预防病因的预后。
