由伐昔洛韦引起的对称性药物相关性擦烂和屈侧疹

Symmetrical drug-related intertriginous and flexural exanthema caused by valacyclovir.

作者信息

Daito Junko, Hanada Keiji, Katoh Norito, Katoh Sayoko, Sakamoto Kakei, Asai Jun, Takenaka Hideya, Kishimoto Saburo

机构信息

Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

出版信息

Dermatology. 2009;218(1):60-2. doi: 10.1159/000167829. Epub 2008 Oct 31.

DOI:10.1159/000167829

PMID:18974630

Abstract

Drug-related eruptions that appear only on intertriginous or flexural folds and in gluteal areas have recently been termed symmetrical drug-related intertriginous and flexural exanthema (SDRIFE). We report a case of a 56-year-old woman with acute erythematous rash in the intertriginous areas after treatment with the L-valine ester of acyclovir, valacyclovir. Oral-challenge tests resulted in erythematous pruritic rash in the intertriginous area by valacyclovir. The patient was diagnosed as having SDRIFE due to valacyclovir.

摘要

仅出现在间擦部位或褶皱处以及臀部区域的药物相关皮疹最近被称为对称性药物相关间擦疹和褶皱疹（SDRIFE）。我们报告一例56岁女性，在用阿昔洛韦的L-缬氨酸酯（伐昔洛韦）治疗后，间擦部位出现急性红斑皮疹。口服激发试验显示伐昔洛韦导致间擦部位出现红斑瘙痒性皮疹。该患者被诊断为因伐昔洛韦引起的SDRIFE。